H.C. TAI LAB
@ NTU CHEM
Publications
Page Link: Google Scholar Profile for Prof. Hwa-Ching Tai
(26) Lkhagva, A.; Shen, C. C.; Leung, Y. S.; Tai, H. C.* Comparative study of five different amine-derivatization methods for metabolite analyses by liquid chromatography-tandem mass spectrometry. J. Chromatogr. A, 2019, advanced online publication, https://doi.org/10.1016/j.chroma.2019.460536.
(25) Lu, B. J.; Li J. R.; Tai, H. C.; Cai, W.; Tseng H. H.; Hsieh, Y. T.* A facile ionic-liquid pretreatment method for the examination of archaeological wood by scanning electron microscopy. Sci. Rep., 2019, 9, 13253.
(24) Pei, J. C.; Hung, W. L.; Lin, B. X.; Shih, M. H.; Lu, L. Y.; Luo, D. Z.; Tai, H. C.; Studer, V.; Min, M. Y.; Lai, W. S.* Therapeutic potential and underlying mechanism of sarcosine (N-methylglycine) in N-methyl-D-aspartate (NMDA) receptor hypofunction models of schizophrenia. J. Psychopharmacol., 2019, 33, 1288-1302.
(23) Tai, H. C.*; Shen Y. P.; Lin, J. H.; Chung, D. T. Acoustic Evolution of Old Italian Violins from Amati to Stradivari. Proc. Natl. Acad. Sci., U.S.A. 2018, 115, 5926-5931. (Reported by The Times, The Guardian, BBC Radio, and dozens of international media outlets) PDF
(22) Wu, H. Y.; Kuo, P. C.; Wang, Y. T.; Lin, H. T.; Roe, A. D., Wang, B. Y.; Han, C. L.; Hyman, B. T.; Chen, Y. J.; Tai, H. C.* β-amyloid induces pathology-related patterns of tau hyperphosphorylation at synaptic terminals. J. Neuropathol. Exp. Neurol. 2018, 77, 814-826. PDF
(21) Guo, Z. H.; Yang, C. I.; Ho, C. I.; Huang, S. J.; Chen, Y. C.; Tai, H. C.; Chan, J. C. C.* Fibrillization of Beta-Amyloid Peptides via Chemically Modulated Pathway. Chem. Eur. J., 2018, 24, 4939-4943. PDF
(20) Zhou, J. F.; Tai, H. C.* The Study of Postmortem Human Synaptosomes for Understanding Alzheimer's Disease and Other Neurological Disorders: A Review. Neurology and Therapy, 2017, 6, 57-68. PDF
(19) Tai, H. C.*; Li, G. C.; Huang, S. J.; Jhu, C. R.; Chung, J. H.; Wang, B. Y.; Hsu, C. S.; Brandmair, B.; Chung, D. T.; Chen, H. M.; Chan, J. C. C. Chemical distinctions between Stradivari’s maple and modern tonewood. Proc. Natl. Acad. Sci. U.S.A., 2017, 114, 27-32. (Reported by The New York Times, The Washington Post, The Times and over 100 international media outlets) PDF
(18) Chen, Y. H.; Hsu, H. Y.; Yeh, M. T.; Chen, C. C.; Huang, C. Y.; Chung, Y. H.; Chang, Z. F.; Kuo, W. C.; Chan, N. L.; Weng, J. H.; Chung, B. C.; Chen, Y. J; Jian, C. B.; Shen, C. C.; Tai, H. C.; Sheu, S. Y.; Fang, J. M.* Chemical Inhibition of Human Thymidylate Kinase and Structural Insights into the Phosphate Binding Loop and Ligand-induced Degradation. J. Med. Chem. 2016, 59, 9906–9918. PDF
(17) Lin, J. M.; Tsai ,Y. T.; Liu, Y. H.; Lin Y.; Tai, H. C.*; Chen. C. S.* Identification of 2-oxohistidine interacting proteins using E. coli proteome chips. Mol. Cell. Proteomics. 2016, 15, 3581-3593. PDF
(16) Huang, C. F.; Liu, Y. H.; Tai, H. C.* Synthesis of peptides containing 2-oxohistidine residues and their characterization by liquid chromatography-tandem mass spectrometry. J. Peptide Sci. 2015, 21, 114-9. PDF
(15) Yang, C. I.; Tsai, B. N.; Huang, S. J.; Wang, T. Y.; Tai, H. C.; Chan, J. C.* Aggregation of Beta-Amyloid Peptides Proximal to Zwitterionic Lipid Bilayers. Chem. Asian. J. 2015, 10, 1967-71. PDF
(14) Tai, H. C. (2014). Role of timbre memory in evaluating Stradivari violins. Proc. Natl. Acad. Sci. U.S.A., 111, E2778. PDF
(13) Tai, H. C.*; Wang, B. Y.; Serrano-Pozo, A.; Frosch, M. P.; Spires-Jones, T. L.; Hyman, B. T.* Frequent and symmetric deposition of misfolded tau oligomers within presynaptic and postsynaptic terminals in Alzheimer’s disease. Acta Neuropath. Comm., 2014, 2, 146. PDF
(12) Chen C. C.; Su, W. C.; Huang, B. Y.; Chen, Y. J.; Tai, H. C.*; Obena, R. P.* Interaction modes and approaches to glycopeptide and glycoprotein enrichment. Analyst, 2014, 139, 688-704. PDF
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(11) Perez-Nievas, B. G.; Stein, T.; Tai, H. C.; Dols-Icardo, O.; Scotton, T. C.; Barroeta-Espar, I.; Fernandez-Carballo, L.; de Munain. E. L.; Perez, J.; Serrano-Pozo, A.; Frosch, M. P.; Lowe, V.; Parisi, J. E.; Petersen, R. C.; Ikonomovic, M. D.; Lopez. O. L.; Klunk, W.; Hyman, B. T.; Gomez-Isla, T.* Dissecting phenotypic traits linked to human resilience to Alzheimer's pathology. Brain, 2013, 136, 2510-26. PDF
(10) Kopeikina, K. J.; Polydoro, M.; Tai, H. C.; Yaeger. E.; Carlson, G. A.; Pitstick, R.; Hyman, B. T.; Spires-Jones, T. L.* Synaptic alteration in the rTg4510 mouse model of tauopathy. J. Comp. Neurol. 2013, 521, 1334-53. PDF
(9) Taylor, A. M.*; Wu, J.; Tai, H. C.; Schuman, E. M.* Axonal translation of β-catenin regulates synaptic vesicle dynamics. J. Neurosci., 2013, 33, 5584-9. PDF
(8) Tai, H. C.; Serrano-Pozo, A.; Hashimoto, T.; Frosch, M. P.; Spires-Jones, T. L.; Hyman, B. T.* The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system. Am. J. Path., 2012, 181, 1426-35. (ESI Highly Cited Paper in 2019) PDF
(7) Koffie, R. M.; Hashimoto, T.; Tai, H. C.; Serrano-Pozzo, A.; Joyner, D.; Hou, S.; Kopeikina, K. J.; Frosch, M. P.; Lee, V. M.; Holtzman, D. M.; Hyman, B. T.; Spires-Jones, T. L.* Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-beta. Brain, 2012, 135, 2155-68. PDF
(6) Tai, H. C.; Besche, H.; Goldberg, A. L.; Schuman, E. M.* Characterization of the brain 26S proteasome and its interacting proteins. Front. Mol. Neurosci. 2010, 3, 12. PDF
(5) Tai, H. C.; Schuman, E. M.* Angelman syndrome: Finding the lost Arc. Cell, 2010, 140, 608-610. PDF
(4) Tai, H. C.; Schuman, E. M.* Ubiquitin, the proteasome and protein degradation in neuronal function and dysfunction. Nat. Rev. Neurosci., 2008, 9, 826-838. PDF
(3) Tai, H. C.; Schuman, E. M.* MicroRNA: MicroRNAs reach out into dendrites. Curr. Biol., 2006, 16, R121-123. PDF
(2) Lin, W. Y.; Murugesh, M. G.; Sudhakar, S.; Yang, H. C.; Tai, H. C.; Chang, C. S.; Liu, Y. H.; Wang, Y.; Chen, I.W.; Chen, C. H.; Luh, T. Y.* On the rigidity of polynorbornenes with dipolar pendant groups. Chem. Eur. J., 2005, 12, 324-330. PDF
(1) Tai, H. C.; Khidekel, N.; Ficarro, S. B.; Peters, E.C.; Hsieh-Wilson, L. C.* Parallel identification of O-GlcNAc modified proteins from cell lysates. J. Am. Chem. Soc., 2004, 126, 10500-10501. PDF
Patents
US Patent #7,332,355. Hsieh-Wilson, L., Khidekel, N., Tai, H. C., Arndt, S. “Method and compositions for the detection of protein glycosylation.” Issued Feb 19, 2008.
US Patent #7,842,517. Hsieh-Wilson, L., Khidekel, N., Tai, H. C., Arndt, S. “Method and compositions for the detection of protein glycosylation.” Issued Nov 30, 2010.
US Patent #8,383,425. Hsieh-Wilson, L., Khidekel, N., Tai, H. C., Arndt, S. “Method and compositions for the detection of protein glycosylation.” Issued Feb 26, 2013.
US Patent #8,927,300. Hsieh-Wilson, L., Khidekel, N., Tai, H. C., Arndt, S. “Method and compositions for the detection of protein glycosylation.” Issued Jan 6, 2015.
US Patent #9,689,022. Hsieh-Wilson, L., Khidekel, N., Tai, H. C., Arndt, S. “Method and compositions for the detection of protein glycosylation.” Issued Jun 27, 2017.